Endocrine Abstracts

The tumor microenvironment can comprise more than 50% of the tumor mass and includes resident and infiltrative non-tumor cells, as well as extracellular matrix proteins, signaling molecules, and blood and lymph vessels (Balkwill et al., 2012). In recent years, the tumor microenvironment has begun to be considered both a prognostic tool and a therapeutic target (Hui and Chen, 2015). While the existence of the tumor microenvironment is well accepted and described in numerous can...

Introduction: Although the metabolic impact of Cushing’s syndrome and hypercortisolemia are well known, the metabolic impact of ACTH is less established.Objective: To identify differences in the glucidic, lipid and bone metabolism in ACTH-dependent versus ACTH-independent Cushing’s syndrome.Methods: Retrospective, cross-sectional study of 99 patients with Cushing’s syndrome (54 with ACTH-dependent Cushing’s synd...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

Introduction: Zinc homeostasis is involved in numerous physiological and pathological conditions, ranging from type 1 and type 2 diabetes to memory impairment and cancer, and is determined by at least 28 genes, including 24 SLC (Solute Carrier) family members and 4 MTs (Metallothioneins). To explore the potential role of zinc homeostasis in MetS (metabolic syndrome) and IR (insulin resistance), we investigated 28...

Background: Tumour microenvironment (TME) can comprise >50% of the tumour mass and includes non-tumour cells like immune cells and fibroblasts, as well as extracellular matrix, signaling molecules, and blood and lymph vessels. In recent years, TME has begun to be considered both a prognostic tool and a therapeutic target. While the existence of TME is well accepted and described in numerous cancers, little is known about the TME of pituitary neuroendocrine tumours (PitNETs...